Unlike the SSL 12 or the iConnectivity interfaces, you cannot control CueMix 5 from a mobile app. If you are using the mk5 as a standalone mixer at a gig, you have to remember the button combos on the front panel (which are clunky). You cannot pull out an iPad to adjust the reverb send on the fly.
While stable, the Windows driver requires you to manage sample rate conflicts manually. If your DAW is at 48kHz and YouTube is playing a 44.1kHz video, one of them will go silent unless you let Windows resample (which adds latency). This is a Windows architecture problem, not exclusively MOTU's, but competing interfaces like RME handle this with a more robust internal clocking manager.
The hardware gives you the pristine conversion. The software gives you the control. Together, they make the UltraLite-mk5 the only interface you will need until you decide to spend $3,000 on a boutique system.
Unlike the Universal Audio Volt or Apollo series, CueMix 5 does not allow you to load third-party VSTs. You are stuck with the stock EQ and Dynamics. For 99% of tracking scenarios, this is fine. For the 1% who want to track through a specific guitar amp sim, you are routing through the DAW anyway. Part 5: The Verdict – Software That Grows With You The MOTU UltraLite-mk5’s software is a case study in utility over vanity .